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Article

Four structural risk factors identify most fibril-forming kappa light chains

1 Jan 2000

Abstract excerpt

Antibody light chains (LCs) comprise the most structurally diverse family of proteins involved in amyloidosis. Many antibody LCs incorporate structural features that impair their stability and solubility, leading to their assembly into fibrils and to their subsequent pathological deposition when produced in excess during multiple myeloma and primary amyloidosis. The particular amino acid variations in antibody...

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Share to Amyloidosis: Diagnosis, Treatment, Outcomes
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PMID: 11019861
DOI: 10.3109/13506120009146835

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