Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of clonal immunoglobulin λ light-chain gene rearrangements in AL amyloidosis using next-generation sequencing

16 Aug 2021

Abstract excerpt

Amyloid light-chain (AL) amyloidosis is caused by deposition of abnormally folded clonal immunoglobulin (Ig) light chains made by malignant plasma cells in the bone marrow (BM), leading to multiorgan dysfunction. However, little is known of the factors that regulate the organ tropism of amyloid deposition in this disease. We aimed to identify the clonal composition of Igλ light-chain variable region (IGLV) genes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloidosis: Diagnosis, Treatment, Outcomes
Share to Chronic Lymphocytic Leukemia Research
Share to Chronic Myeloid Leukemia Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34411686
DOI: 10.1016/j.exphem.2021.08.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of clonal immunoglobulin λ light-chain gene rearrangements in AL amyloidosis using next-generation sequencingPMID 34411686Read ↗

An updated AL-base reveals ranked enrichment of immunoglobulin light chain variable genes in AL amyloidosis.Semantic proximity Read ↗

An updated AL-Base reveals ranked enrichment of immunoglobulin light chain variable genes in AL amyloidosisSemantic proximity Read ↗

Sequence diversity of kappa light chains from patients with AL amyloidosis and multiple myeloma.Semantic proximity Read ↗

Analysis of the complete lambda light chain germline usage in patients with AL amyloidosis and dominant heart or kidney involvementSemantic proximity Read ↗

Structural Consequences of Antibody Light Chain N Glycosylation in AL AmyloidosisSemantic proximity Read ↗

Phenotypic, transcriptomic, and genomic features of clonal plasma cells in light-chain amyloidosis.Semantic proximity Read ↗

Analysis of somatic hypermutation and antigenic selection in the clonal B cell in immunoglobulin light chain amyloidosis (AL).Semantic proximity Read ↗

Role of the mechanisms for antibody repertoire diversification in monoclonal light chain deposition disorders: when a friend becomes foeSemantic proximity Read ↗

Clonal immunoglobulin light chain variable region germline gene use in AL amyloidosis: association with dominant amyloid‐related organ involvement and survival after stem cell transplantationSemantic proximity Read ↗

Cellular diversity and genetic alterations in light chain amyloidosis and amyloidosis with co-occurring multiple myelomaSemantic proximity Read ↗

Immunoglobulin light chain amyloid aggregation.Semantic proximity Read ↗

Functional Subsets of Plasma Cells Associated with Amyloid Production and Venetoclax Sensitivity in Light Chain AmyloidosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.