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Article

Structural Consequences of Antibody Light Chain N Glycosylation in AL Amyloidosis

2024-10-17

Abstract excerpt

Antibody light chains form amyloid fibrils that lead to progressive tissue damage in amyloid light chain (AL) amyloidosis. The properties of each patient’s unique light chain appear to determine its propensity to form amyloid. One factor is N-glycosylation, which is more frequent in amyloid-associated light chains than in light chains from the normal immune repertoire. However, the mechanisms underlying this assoc...

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Literature Corpus work
bb93d780-e183-5f35-849f-f40e87fe7faf
DOI
10.20944/preprints202410.1407.v1
Open publication

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Structural Consequences of Antibody Light Chain N Glycosylation in AL AmyloidosisDOI 10.20944/preprints202410.1407.v1
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