Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequence diversity of kappa light chains from patients with AL amyloidosis and multiple myeloma.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis - 1 Jun 2024

Schreiner Sarah, Berghaus Natalie, Poos Alexandra M, Raab Marc S, Besemer Britta, Fenk Roland, Goldschmidt Hartmut, Mai Elias K, Müller-Tidow Carsten, Weinhold Niels, Hegenbart Ute, Huhn Stefanie, Schönland Stefan O

Abstract excerpt

BACKGROUND: AL amyloidosis (AL) results from the misfolding of immunoglobulin light chains (IG LCs). Aim of this study was to comprehensively analyse kappa LC sequences from AL patients in comparison with multiple myeloma (MM). OBJECTIVE: We analysed IGKV/IGKJ usage and associated organ tropism and IGKV1/D-33 in terms of mutational analysis and theoretical biochemical properties. MATERIAL AND METHODS: cDNA and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Amyloidosis: Diagnosis, Treatment, Outcomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin kappa-Chains

Share to Monoclonal and Polyclonal Antibodies Research

Share to Multiple Myeloma

Share to Multiple Myeloma Research and Treatments

Share to Mutation

Source

Identifiers

PMID: 38206120
DOI: 10.1080/13506129.2023.2295221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequence diversity of kappa light chains from patients with AL amyloidosis and multiple myeloma.PMID 38206120Read ↗

An updated AL-base reveals ranked enrichment of immunoglobulin light chain variable genes in AL amyloidosis.Semantic proximity Read ↗

An updated AL-Base reveals ranked enrichment of immunoglobulin light chain variable genes in AL amyloidosisSemantic proximity Read ↗

Analysis of the complete lambda light chain germline usage in patients with AL amyloidosis and dominant heart or kidney involvementSemantic proximity Read ↗

Identification of clonal immunoglobulin λ light-chain gene rearrangements in AL amyloidosis using next-generation sequencingSemantic proximity Read ↗

Role of complementarity-determining regions 1 and 3 in pathologic amyloid formation by human immunoglobulin κ1 light chainsSemantic proximity Read ↗

The Conformational Landscape of AlphaFold2-Predicted Amyloidogenic Light Chains and Their Correlation With VL Domain Mutations and Aggregation Propensity.Semantic proximity Read ↗

Heterogeneity in Primary Structure, Post-Translational Modifications, and Germline Gene Usage of Nine Full-Length Amyloidogenic κ1 Immunoglobulin Light ChainsSemantic proximity Read ↗

Role of Complementarity-Determining Regions 1 and 3 in Pathologic Amyloid Formation by Human Immunoglobulin κ1 Light ChainsSemantic proximity Read ↗

Diversity and diversification of light chains in myeloma: the specter of amyloidogenesis by proxy.Semantic proximity Read ↗

Comparison of IGLV2-14 light chain sequences of patients with AL amyloidosis or multiple myeloma.Semantic proximity Read ↗

Four structural risk factors identify most fibril-forming kappa light chainsSemantic proximity Read ↗

Clarifying immunoglobulin gene usage in systemic and localized immunoglobulin light-chain amyloidosis by mass spectrometrySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.