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Analysis of the complete lambda light chain germline usage in patients with AL amyloidosis and dominant heart or kidney involvement

25 Feb 2022

Abstract excerpt

Light chain amyloidosis is one of the most common forms of systemic amyloidosis. The disease is caused by the misfolding and aggregation of immunoglobulin light chains to insoluble fibrils. These fibrils can deposit in different tissues and organs such as heart and kidney and cause organ impairments that define the clinical presentation. In this study, we present an overview of IGLV-IGLJ and IGLC germline...

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PMID: 35213605
DOI: 10.1371/journal.pone.0264407

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