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Article

Plasminogen mediates the pathological effects of urokinase-type plasminogen activator overexpression.

The American journal of pathology - 1 Jun 2004

Bolon Isabelle, Zhou Hong-Ming, Charron Yves, Wohlwend Annelise, Vassalli Jean-Dominique

Abstract excerpt

Increased expression of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) is associated with different pathological conditions. Both uPAR-mediated signaling and plasmin-catalyzed extracellular proteolysis may contribute to pathogenesis. To evaluate the involvement of plasminogen in such circumstances, we have taken advantage of transgenic mouse models in which overexpression of uPA and/or uPAR in...

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Identifiers

PMID: 15161662
DOI: 10.1016/S0002-9440(10)63786-8
PMCID: PMC1615761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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