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Article

The plasminogen receptor, Plg-RKT, is essential for mammary lobuloalveolar development and lactation.

Journal of thrombosis and haemostasis : JTH - 1 May 2018

Miles L A, Baik N, Bai H, Makarenkova H P, Kiosses W B, Krajewski S, Castellino F J, Valenzuela A, Varki N M, Mueller B M, Parmer R J

Abstract excerpt

Essentials Plg-RKT-/- female mice give birth, but no offspring of Plg-RKT-/- female mice survive to weaning. Causal mechanisms of potential lactational failure in Plg-RKT-/- mice are unknown. Plg-RKT regulates extracellular matrix remodeling, cell proliferation, apoptosis, fibrin surveillance. Plg-RKT is essential for lactogenesis and mammary lobuloalveolar development. SUMMARY: Background Lactational competence...

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Identifiers

PMID: 29495105
DOI: 10.1111/jth.13988
PMCID: PMC5965281

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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