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Article

Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator.

Cell - 10 Aug 1990

Heckel J L, Sandgren E P, Degen J L, Palmiter R D, Brinster R L

Abstract excerpt

Spontaneous intestinal and intra-abdominal bleeding was observed in a high percentage of newborn transgenic mice carrying the murine urokinase-type plasminogen activator (uPA) gene linked to the albumin enhancer/promoter. These hemorrhagic events were directly related to transgene expression in the liver and the development of high plasma uPA levels. Two lines were established from surviving founder mice that...

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PMID: 1696178
DOI: 10.1016/0092-8674(90)90010-c

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