Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator.

doi:10.1016/0092-8674(90)90010-c

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Article

Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator.

Cell - 10 Aug 1990

Heckel J L, Sandgren E P, Degen J L, Palmiter R D, Brinster R L

Abstract excerpt

Spontaneous intestinal and intra-abdominal bleeding was observed in a high percentage of newborn transgenic mice carrying the murine urokinase-type plasminogen activator (uPA) gene linked to the albumin enhancer/promoter. These hemorrhagic events were directly related to transgene expression in t...

Topics

Animals
Base Sequence
Blotting, Northern
Fibrinogen
Gastrointestinal Hemorrhage
Gene Expression
Growth Hormone
Humans
Liver
Mice
Mice, Transgenic
Molecular Sequence Data
Nucleic Acid Hybridization
Oligonucleotide Probes
Phenotype
Plasminogen Activators
Platelet Count
Protein Precursors

Source

Open in PubMed

Identifiers

PMID: 1696178
DOI: 10.1016/0092-8674(90)90010-c

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1696178-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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