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Transforming Growth Factor-Beta and Urokinase-Type Plasminogen Activator: Dangerous Partners in Tumorigenesis—Implications in Skin Cancer

18 Jul 2013

Abstract excerpt

Transforming growth factor-beta (TGF- β ) is a pleiotropic factor, with several different roles in health and disease. TGF- β has been postulated as a dual factor in tumor progression, since it represses epithelial tumor development in early stages, whereas it stimulates tumor progression in advanced stages. During tumorigenesis, cancer cells acquire the capacity to migrate and invade surrounding tissues and to...

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PMID: 23984088
DOI: 10.1155/2013/597927

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