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Article

Mice deficient in urokinase-type plasminogen activator have delayed healing of tympanic membrane perforations.

PloS one - 1 Jan 2012

Shen Yue, Guo Yongzhi, Du Chun, Wilczynska Malgorzata, Hellström Sten, Ny Tor

Abstract excerpt

Mice deficient in plasminogen, the precursor of plasmin, show completely arrested healing of tympanic membrane (TM) perforations, indicating that plasmin plays an essential role in TM healing. The activation of plasminogen to plasmin is performed by two plasminogen activators (PAs), urokinase-type PA (uPA) and tissue-type PA (tPA). To elucidate the functional roles of PAs in the healing of TM perforations, we...

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Identifiers

PMID: 23236466
DOI: 10.1371/journal.pone.0051303
PMCID: PMC3517469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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