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Article

Urokinase-type plasminogen activator and its receptor synergize to promote pathogenic proteolysis.

The EMBO journal - 1 Sept 2000

Zhou H M, Nichols A, Meda P, Vassalli J D

Abstract excerpt

Urokinase-type plasminogen activator (uPA) is a potent catalyst of extracellular proteolysis, which also binds to a high-affinity plasma membrane receptor (uPAR). Binding of uPA may influence pericellular proteolysis and/or activate intracellular signal transduction. Transgenic mice overexpressing either uPA or uPAR in basal epidermis and hair follicles had no detectable cutaneous alterations. In contrast,...

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Identifiers

PMID: 10970872
DOI: 10.1093/emboj/19.17.4817
PMCID: PMC302082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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