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Article

ATR Pathway Is the Primary Pathway for Activating G2/M Checkpoint Induction After Re-replication

24 Aug 2007

Abstract excerpt

DNA replication is tightly controlled to ensure accurate chromosome duplication and segregation in each cell cycle. Inactivation of Geminin, an inhibitor of origin licensing, leads to re-replication in human tumor cells within the same cell cycle and triggers a G(2)/M checkpoint. We find that the primary pathway to signal that re-replication has been detected is the ATR kinase and the Rad9-Rad1-Hus1 (9-1-1) clamp...

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Identifiers

PMID: 17716975
DOI: 10.1074/jbc.m705178200

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