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Article

Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability

12 Jul 2006

Abstract excerpt

The activity of human Cdt1 is negatively regulated by multiple mechanisms. This suggests that Cdt1 deregulation may have a deleterious effect. Indeed, it has been suggested that overexpression of Cdt1 can induce rereplication in cancer cells and that rereplication activates Ataxia-telangiectasia-mutated (ATM) kinase and/or ATM- and Rad3-related (ATR) kinase-dependent checkpoint pathways. In this report, we...

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Identifiers

PMID: 16835273
DOI: 10.1242/jcs.03031

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