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Article

Myeloperoxidase (MPO) -463G->A reduces MPO activity and DNA adduct levels in bronchoalveolar lavages of smokers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2004

Van Schooten Frederik J, Boots Agnes W, Knaapen Ad M, Godschalk Roger W L, Maas Lou M, Borm Paul J A, Drent Marjolein, Jacobs Jan A

Abstract excerpt

The myeloperoxidase (MPO) -463G-->A genetic polymorphism is associated with a reduced risk for lung cancer, but the underlying mechanism is not yet elucidated. Therefore, the impact of this polymorphism on MPO activity and lipophilic DNA adducts was studied in respectively bronchoalveolar lavage (BAL) fluid and cells, from 106 smoking Caucasian lung patients. MPO activity was determined spectrophotometrically,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15159316

Genes

MPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Myeloperoxidase (MPO) -463G->A reduces MPO activity and DNA adduct levels in bronchoalveolar lavages of smokers.PMID 15159316Read ↗

Myeloperoxidase -463 (G-->A) polymorphism associated with lower risk of lung cancer.Semantic proximity Read ↗

Myeloperoxidase (MPO) genotype and lung cancer histologic types: the MPO -463 A allele is associated with reduced risk for small cell lung cancer in smokers.Semantic proximity Read ↗

Genetic polymorphism in myeloperoxidase but not GSTM1 is associated with risk of lung squamous cell carcinoma in a Chinese population.Semantic proximity Read ↗

Point: myeloperoxidase -463G --> a polymorphism and lung cancer risk.Semantic proximity Read ↗

Substantially reduced risk of cancer of the aerodigestive tract in subjects with variant--463A of the myeloperoxidase gene.Semantic proximity Read ↗

Myeloperoxidase -463G>A polymorphism and risk of primary lung cancer in a Korean population.Semantic proximity Read ↗

The MPO-463G>A polymorphism and lung cancer risk: a meta-analysis based on 22 case-control studies.Semantic proximity Read ↗

Myeloperoxidase G463A polymorphism and risk of lung cancer.Semantic proximity Read ↗

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Myeloperoxidase: new polymorphisms and relation with lung cancer risk.Semantic proximity Read ↗

Counterpoint: the myeloperoxidase -463G-->a polymorphism does not decrease lung cancer susceptibility in Caucasians.Semantic proximity Read ↗

Myeloperoxidase -463 G/A polymorphism is associated with lung cancer risk: A meta-analysis with 7420 cases and 9132 controls.Semantic proximity Read ↗

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