Article
Myeloperoxidase (MPO) genotype and lung cancer histologic types: the MPO -463 A allele is associated with reduced risk for small cell lung cancer in smokers.
International journal of cancer - 10 Dec 2002
Dally Heike, Gassner Kai, Jäger Birgit, Schmezer Peter, Spiegelhalder Bertold, Edler Lutz, Drings Peter, Dienemann Hendrik, Schulz Volker, Kayser Klaus, Bartsch Helmut, Risch Angela
Abstract excerpt
MPO participates in the metabolic activation of tobacco carcinogens such as PAHs. A frequent MPO -463 G-->A polymorphism in the promoter region reduces MPO transcription and has been correlated with >4-fold lower benzo[a]pyrene-DNA adduct levels in the skin of coal tar-treated patients. Four of 7 case-control studies found significantly reduced lung cancer risk associated with the A allele. Due to their different...
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