Article
Counterpoint: the myeloperoxidase -463G-->a polymorphism does not decrease lung cancer susceptibility in Caucasians.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2002
Xu Li-Lian, Liu Geoffrey, Miller David P, Zhou Wei, Lynch Thomas J, Wain John C, Su Li, Christiani David C
Abstract excerpt
The myeloperoxidase (MPO) G-to-A substitution polymorphism in the promoter region of the MPO gene has been associated with a 40-70% reduction in lung cancer risk in several studies, although a recent nested case-control study disputes these findings. MPO is involved in the activation of a number of procarcinogens, including benzo(a)pyrene. The variant A allele has been shown to reduce MPO mRNA expression, thus...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.