Article
Myeloperoxidase -463G>A polymorphism and risk of primary lung cancer in a Korean population.
Cancer detection and prevention - 1 Jan 2006
Park Jae Hyung, Park Jung Min, Kim Eun Jin, Cha Sung Ick, Lee Eung Bae, Kim Chang Ho, Kam Sin, Jung Tae Hoon, Park Jae Yong
Abstract excerpt
BACKGROUND: Myeloperoxidase (MPO) contributes to pulmonary carcinogenesis through activation of a wide range of tobacco smoke procarcinogens, including benzo[a]pyrene and aromatic amines. A -463G>A polymorphism in the promoter region of the MPO gene has been shown to reduce MPO expression and activity. It is therefore possible that carriers of the -463A allele may be at decreased risk of lung cancer. To test this...
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