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Article

The VHL tumor suppressor: master regulator of HIF.

Current pharmaceutical design - 1 Jan 2009

Haase Volker H

Abstract excerpt

Hypoxia-Inducible Factors (HIFs) are heterodimeric oxygen-sensitive basic helix-loop-helix transcription factors that play central roles in cellular adaptation to low oxygen environments. The von-Hippel Lindau tumor suppressor (pVHL) is the substrate recognition component of an E3 ubiquitin ligase and functions as a master regulator of HIF activity by targeting the hydroxylated HIF-alpha subunit for...

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Source

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Identifiers

PMID: 19671042
DOI: 10.2174/138161209789649394
PMCID: PMC3622710

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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The VHL tumor suppressor: master regulator of HIF.PMID 19671042Read ↗

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Systemic <i>VHL</i> gene functions and the VHL diseaseSemantic proximity Read ↗

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.Semantic proximity Read ↗

von Hippel-Lindau disease: recent advances and therapeutic perspectives.Semantic proximity Read ↗

Recent advances in etiology and treatment of von Hippel-Lindau Disease (VHLD).Semantic proximity Read ↗

Hypoxia-inducible factor underlies von Hippel-Lindau disease stigmataSemantic proximity Read ↗

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.Semantic proximity Read ↗

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