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Article

Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

The Journal of biological chemistry - 18 Oct 2002

Huang Jianhe, Zhao Quan, Mooney Sharon M, Lee Frank S

Abstract excerpt

Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor induced by hypoxia. Under normoxic conditions, site-specific proline hydroxylation of the alpha subunits of HIF allows recognition by the von Hippel-Lindau tumor suppressor protein (VHL), a component of an E3 ubiquitin ligase complex that targets these subunits for degradation by the ubiquitin-proteasome pathway. Under hypoxic conditions, this...

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Source

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Identifiers

PMID: 12181324
DOI: 10.1074/jbc.M206955200
PMCID: PMC1828037

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.PMID 12181324Read ↗

Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation.Semantic proximity Read ↗

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A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove.Semantic proximity Read ↗

Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors.Semantic proximity Read ↗

Identification of an alternative mechanism of degradation of the hypoxia-inducible factor-1alpha.Semantic proximity Read ↗

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