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Article

A conserved family of prolyl-4-hydroxylases that modify HIF.

Science (New York, N.Y.) - 9 Nov 2001

Bruick R K, McKnight S L

Abstract excerpt

Mammalian cells respond to changes in oxygen availability through a conserved pathway that is regulated by the hypoxia-inducible factor (HIF). The alpha subunit of HIF is targeted for degradation under normoxic conditions by a ubiquitin-ligase complex that recognizes a hydroxylated proline residue in HIF. We identified a conserved family of HIF prolyl hydoxylase (HPH) enzymes that appear to be responsible for...

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Share to Cell Hypoxia
Share to Hydroxylation
Share to Hydroxyproline

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to L-Lactate Dehydrogenase

Share to Procollagen-Proline Dioxygenase

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Source

Identifiers

PMID: 11598268
DOI: 10.1126/science.1066373

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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