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Article

Identification of an alternative mechanism of degradation of the hypoxia-inducible factor-1alpha.

The Journal of biological chemistry - 24 Oct 2008

André Helder, Pereira Teresa S

Abstract excerpt

The hypoxia-inducible factor-1alpha (HIF-1alpha) is a master regulator of the cellular response to decreased oxygen levels. This transcription factor is highly unstable at normal oxygen concentrations and is rapidly stabilized by hypoxia. At normoxia two specific proline residues (Pro(402) and Pro(563)) of mHIF-1alpha are hydroxylated and recognized by the von Hippel-Lindau E3 ubiquitin ligase (pVHL) complex,...

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Identifiers

PMID: 18694926
DOI: 10.1074/jbc.M805919200
PMCID: PMC2662024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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