Article

RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response.

2019-01-29

Abstract excerpt

<h4>Background: </h4> Hypoxia-inducible factor (HIF) transcription factors are well known to control the transcriptional response to hypoxia. Given the importance of cellular response to hypoxia, a number of pharmacological agents to interfere with this pathway have been developed and entered pre-clinical or clinical trial phases. However, how similar or divergent the transcriptional response elicited by different...

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Literature Corpus work: e28fdc7d-f3a4-5359-867b-611a7e3851a2
DOI: 10.12688/wellcomeopenres.15044.1

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