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Article

Prolyl hydroxylase domain 2 protein suppresses hypoxia-induced endothelial cell proliferation.

Hypertension (Dallas, Tex. : 1979) - 1 Jan 2007

Takeda Kotaro, Fong Guo-Hua

Abstract excerpt

Prolyl hydroxylase domain 2 protein (PHD2) signals the degradation of hypoxia-inducible factor (HIF)-1alpha by hydroxylating specific prolyl residues located within oxygen-dependent degradation domains. As expected, endothelial cells (ECs) overexpressing PHD2 had reduced HIF-1alpha and vascular endothelial growth factor-A expression and failed to accelerate their proliferation in response to hypoxia....

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Source

Identifiers

PMID: 17101841
DOI: 10.1161/01.HYP.0000251360.40838.0f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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