Article
Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo.
The EMBO journal - 4 Oct 2006
Kim William Y, Safran Michal, Buckley Marshall R M, Ebert Benjamin L, Glickman Jonathan, Bosenberg Marcus, Regan Meredith, Kaelin William G
Abstract excerpt
Many functions have been assigned to the von Hippel-Lindau tumor suppressor gene product (pVHL), including targeting the alpha subunits of the heterodimeric transcription factor HIF (hypoxia-inducible factor) for destruction. The binding of pVHL to HIFalpha requires that HIFalpha be hydroxylated on one of two prolyl residues. We introduced HIF1alpha and HIF2alpha variants that cannot be hydroxylated on these...
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