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Article

Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo.

The EMBO journal - 4 Oct 2006

Kim William Y, Safran Michal, Buckley Marshall R M, Ebert Benjamin L, Glickman Jonathan, Bosenberg Marcus, Regan Meredith, Kaelin William G

Abstract excerpt

Many functions have been assigned to the von Hippel-Lindau tumor suppressor gene product (pVHL), including targeting the alpha subunits of the heterodimeric transcription factor HIF (hypoxia-inducible factor) for destruction. The binding of pVHL to HIFalpha requires that HIFalpha be hydroxylated...

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Identifiers

PMID: 16977322
DOI: 10.1038/sj.emboj.7601300
PMCID: PMC1589988

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16977322-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo.PMID 16977322Read ↗

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Two sides to every story: the HIF-dependent and HIF-independent functions of pVHLSemantic proximity Read ↗

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Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor gene product.Semantic proximity Read ↗

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