Article
Polymorphism of the Plasmodium falciparum multidrug resistance and chloroquine resistance transporter genes and in vitro susceptibility to aminoquinolines in isolates from the Peruvian Amazon.
The American journal of tropical medicine and hygiene - 1 May 2004
Huaman Maria Cecilia, Roncal Norma, Nakazawa Shusuke, Long Ton That Ai, Gerena Lucia, Garcia Coralith, Solari Lely, Magill Alan J, Kanbara Hiroji
Abstract excerpt
In vitro drug sensitivity to chloroquine (CQ), mefloquine (MQ) and quinine was investigated in 60 culture-adapted Plasmodium falciparum isolates from malaria patients in Padrecocha, a village in the Amazonian Department of Loreto, Peru. All isolates showed resistance to CQ, decreased susceptibili...
Topics
- Animals
- Antimalarials
- Chloroquine
- Drug Resistance, Multiple
- Genes, MDR
- Genotype
- Mefloquine
- Membrane Proteins
- Membrane Transport Proteins
- Mutation
- Parasitic Sensitivity Tests