In vitro antimalarial susceptibility profile and prcrt/pfmdr-1 genotypes of Plasmodium falciparum field isolates from Malawi.

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Article

In vitro antimalarial susceptibility profile and prcrt/pfmdr-1 genotypes of Plasmodium falciparum field isolates from Malawi.

The American journal of tropical medicine and hygiene - 1 Jun 2007

Nkhoma Standwell, Molyneux Malcolm, Ward Stephen

Abstract excerpt

We measured in vitro antimalarial drug susceptibility of 84 Plasmodium falciparum field isolates from Blantyre, Southern Malawi, using the WHO microtest and the lactate dehydrogenase assay. We also genotyped these isolates to investigate whether variation in their absolute drug sensitivity is associated with specific sets of pfcrt and pfmdr-1 mutations harbored by parasites. Our results show that nearly a decade...

Topics

Animals
Antimalarials
Child, Preschool
DNA, Protozoan
Genotype
Humans
Infant
Inhibitory Concentration 50
L-Lactate Dehydrogenase
Malaria, Falciparum
Malawi

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Transport Proteins

Multidrug Resistance-Associated Proteins

Plasmodium falciparum

Point Mutation

Polymerase Chain Reaction

Protozoan Proteins

Statistics, Nonparametric

Source

Open in PubMed

Identifiers

PMID: 17556619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17556619-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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