Article
Delivery of the immunosuppressive antigen Salp15 to antigen-presenting cells by Salmonella enterica serovar Typhimurium aroA mutants.
Infection and immunity - 1 Jun 2004
Motameni Amir-Reza T, Juncadella Ignacio J, Ananthanarayanan Shobana K, Hedrick Michael N, Huet-Hudson Yvette, Anguita Juan
Abstract excerpt
A Salmonella enterica serovar Typhimurium aroA-deficient delivery system was used to target the immunosuppressive protein Salp15 to antigen-presenting cells. In vitro and in vivo infections with Salp15-containing Salmonella resulted in an impaired CD4(+)-T-cell activation, suggesting that the protein was produced by antigen-presenting cells in a physiologically active form.
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.