Article
Induction of SIV capsid-specific CTL and mucosal sIgA in mice immunized with a recombinant S. typhimurium aroA mutant.
Vaccine - 1 Feb 1996
Valentine P J, Meyer K, Rivera M M, Lipps C, Pauza D, Maziarz R T, So M, Heffron F
Abstract excerpt
We have developed a new expression system based on the E. coli groEL promoter. The suicide vector constructed (called APC vector) allows simultaneous attenuation of a Salmonella strain by disruption of the coding sequence for aroA and stable integration of a gene into the bacterial chromosome. High-level expression of antigen is achieved after Salmonella is taken up by macrophages, a major antigen processing cell...
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