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Comparison of abilities of Salmonella enterica serovar typhimurium aroA aroD and aroA htrA mutants to act as live vectors.

Infection and immunity - 1 Oct 2000

Roberts M, Chatfield S, Pickard D, Li J, Bacon A

Abstract excerpt

We compared the ability of Salmonella enterica serovar Typhimurium SL1344 aroA aroD (BRD509) and aroA htrA (BRD807) mutants to act as live vectors for delivery of fragment C of tetanus toxin (FrgC). FrgC was expressed in these strains from either pTETnir15 or pTEThtrA1. BRD509FrgC(+) strains elicited approximately 2-log-higher serum anti-FrgC antibody titers than BRD807FrgC(+) strains. All mice immunized with...

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Identifiers

PMID: 10992518
DOI: 10.1128/IAI.68.10.6041-6043.2000
PMCID: PMC101570

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Source receipt: pubmed, retrieved 7 Sept 2026.

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