Article
Mutant NRASQ61 shares signaling similarities across various cancer types--potential implications for future therapies.
Oncotarget - 15 Sept 2014
Vujic Igor, Posch Christian, Sanlorenzo Martina, Yen Adam J, Tsumura Aaron, Kwong Andrew, Feichtenschlager Valentin, Lai Kevin, Arneson Douglas V, Rappersberger Klemens, Ortiz-Urda Susana M
Abstract excerpt
Oncogenic mutations in the Neuroblastoma Rat Sarcoma oncogene (NRAS) are frequent in melanoma, but are also found in several other cancer types, such as lung cancer, neuroblastoma and colon cancer. We designed our study to analyze changes in NRAS mutant tumor cells derived from malignancies other than melanoma. A variety of small molecule inhibitors as well as their combinations was tested in order to find...
Topics
- Antineoplastic Agents
- Cell Line, Tumor
- Cell Survival
- DNA Mutational Analysis
- Drug Resistance, Neoplasm
- Drug Synergism
- GTP Phosphohydrolases
- Humans
- Immunoblotting
- Membrane Proteins