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Article

Ras-independent oncogenic transformation by an EGF-receptor mutant.

Journal of cell science - 1 Mar 2000

Boerner J L, McManus M J, Martin G S, Maihle N J

Abstract excerpt

Mutations in the ligand-binding domain of the epidermal growth factor receptor have been identified in several types of human cancers, including malignant gliomas. These mutations render signaling by this receptor to be constitutively ligand-independent. In fibroblasts transformed with ligand-independent epidermal growth factor receptor mutants, there is a correlation between the formation of a unique...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10683142
DOI: 10.1242/jcs.113.6.935

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Ras-independent oncogenic transformation by an EGF-receptor mutant.PMID 10683142Read ↗

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