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Article

A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation.

Current biology : CB - 22 Oct 1998

Robinson M J, Stippec S A, Goldsmith E, White M A, Cobb M H

Abstract excerpt

BACKGROUND: Mitogen-activated protein (MAP) kinases are ubiquitous components of many signal transduction pathways. Constitutively active variants have been isolated for every component of the extracellular-signal-regulated kinase 1 (ERK1) and ERK2 MAP kinase pathway except for the ERK itself. RESULTS: To create an activated ERK2 variant, we fused ERK2 to the low activity form of its upstream regulator, the MAP...

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PMID: 9799732
DOI: 10.1016/s0960-9822(07)00485-x

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