A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation.

doi:10.1016/s0960-9822(07)00485-x

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Article

A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation.

Current biology : CB - 22 Oct 1998

Robinson M J, Stippec S A, Goldsmith E, White M A, Cobb M H

Abstract excerpt

BACKGROUND: Mitogen-activated protein (MAP) kinases are ubiquitous components of many signal transduction pathways. Constitutively active variants have been isolated for every component of the extracellular-signal-regulated kinase 1 (ERK1) and ERK2 MAP kinase pathway except for the ERK itself. RE...

Topics

3T3 Cells
Amino Acid Sequence
Animals
Calcium-Calmodulin-Dependent Protein Kinases
Cell Line
Cell Line, Transformed
Cell Nucleus
Codon
Fluorescent Antibody Technique, Indirect
Humans
Luciferases
MAP Kinase Kinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mitogen-Activated Protein Kinase 1

Mitogen-Activated Protein Kinase 3

Mitogen-Activated Protein Kinase Kinases

Mitogen-Activated Protein Kinases

Mutagenesis, Insertional

Source

Open in PubMed

Identifiers

PMID: 9799732
DOI: 10.1016/s0960-9822(07)00485-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9799732-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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