Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Slowly Progressive, Angiotensin II–Independent Glomerulosclerosis in Human (Pro)renin Receptor–Transgenic Rats

9 May 2007

Abstract excerpt

For defining the pathogenic effects of the (pro)renin receptor-transgenic rat, strains that overexpressed the human receptor were generated. Although transgenic rats were normotensive and euglycemic and had a renal angiotensin II (AngII) level that was comparable to that of wild-type rats, transgenic rats developed proteinuria with aging and significant glomerulosclerosis at 28 wk of age. In kidneys of 28-wk-old...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hormonal Regulation and Hypertension
Share to Receptor Mechanisms and Signaling
Share to Renin-Angiotensin System Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17494887
DOI: 10.1681/asn.2006091062

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Slowly Progressive, Angiotensin II–Independent Glomerulosclerosis in Human (Pro)renin Receptor–Transgenic RatsPMID 17494887Read ↗

Elevated blood pressure and heart rate in human renin receptor transgenic rats.Semantic proximity Read ↗

Angiotensin II type 1 receptor overexpression in podocytes induces glomerulosclerosis in transgenic rats.Semantic proximity Read ↗

The hypertensive Ren-2 transgenic rat TGR (mREN2) 27 in hypertension research Characteristics and functional aspectsSemantic proximity Read ↗

Functional expression of the human angiotensinogen gene in transgenic mice.Semantic proximity Read ↗

Physiological characterization of the hypertensive transgenic rat TGR(mREN2)27.Semantic proximity Read ↗

Rats Transgenic for Human Renin and Human Angiotensinogen as a Model for Gestational HypertensionSemantic proximity Read ↗

Blood Pressure Elevation of Tubular Specific (P)RR Transgenic Mice and Lethal Tubular Degeneration due to Possible Intracellular Interactions between (P)RR and Alternative Renin Products.Semantic proximity Read ↗

Transgenic mice as a tool to study the renin-angiotensin system.Semantic proximity Read ↗

Loss of Soluble (Pro)renin Receptor Attenuates Angiotensin-II Induced Hypertension and Renal Injury.Semantic proximity Read ↗

Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes.Semantic proximity Read ↗

Cardiovascular and renal pathologic implications of prorenin, renin, and the (pro)renin receptor: promising young players from the old renin-angiotensin-aldosterone system.Semantic proximity Read ↗

GRK2 knockdown in mice exacerbates kidney injury and alters renal mechanisms of blood pressure regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.