Article
Fcgamma receptors: structure, function and role as genetic risk factors in SLE.
Genes and immunity - 1 Jul 2009
Li X, Ptacek T S, Brown E E, Edberg J C
Abstract excerpt
Over 30 years ago, receptors for the Fc region of IgG (FcgammaR) were implicated in the pathogenesis of systemic lupus erythematosus (SLE). Since those pioneering studies, our knowledge of the structure and function of these FcgammaRs has increased dramatically. We now know that FcgammaR contributes to the regulation of acquired immunity and to the regulation of innate immune responses where FcgammaRs act as...
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