Article
Genomic organization of classical human low-affinity Fcgamma receptor genes.
Genes and immunity - 1 Oct 2002
Su K, Wu J, Edberg J C, McKenzie S E, Kimberly R P
Abstract excerpt
The classical low-affinity Fcgamma receptor genes (FcgammaRIIA, B, C and FcgammaRIIIA, B) are located on chromosome 1q23, a region that shows strong linkage with human systemic lupus erythematosus (SLE) in several genome-wide scans, and family-based association between FcgammaRIIIA and SLE is now established. High homology among the Fcgamma receptor genes, however, has hampered further study of this region. We...
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