Article
A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus.
Proceedings of the National Academy of Sciences of the United States of America - 27 Apr 2010
Willcocks Lisa C, Carr Edward J, Niederer Heather A, Rayner Tim F, Williams Thomas N, Yang Wanling, Scott J Anthony G, Urban Britta C, Peshu Norbert, Vyse Timothy J, Lau Yu Lung, Lyons Paul A, Smith Kenneth G C
Abstract excerpt
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease more prevalent in people of African and Asian origin than Caucasian origin. FcgammaRIIb is an inhibitory Fc receptor with a critical role in immune regulation. Mouse data suggest that FcgammaRIIb deficiency increases susceptibility to autoimmune disease but protects against infection. We show that a SNP in human FCGR2B that abrogates receptor...
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