Article
In vivo derived HIV-1 nef gene products are heterogeneous and lack detectable nucleotide binding activity.
AIDS research and human retroviruses - 1 May 1992
Harris M, Hislop S, Patsilinacos P, Neil J C
Abstract excerpt
Multiple HIV-1 nef genes were cloned from lymphocyte DNA of asymptomatic seropositive individuals by polymerase chain reaction (PCR). Sequence analysis of these clones revealed a unique set of nef variants with premature terminations (PCRnef 1 and 6), mutations at sites of potential posttranslational modification (PCRnef 2 and 3) and deletions. In common with laboratory isolates of nef, strong sequence...
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