Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration.

Clinical genetics - 1 Jun 2004

Wang J, Huff A M, Spence J D, Hegele R A

Abstract excerpt

Plasma total homocysteine (tHcy) concentration, an independent risk factor of atherosclerosis, has numerous genetic and environmental determinants. While the thermolabile polymorphism in MTHFR encoding methylenetetrahydrofolate reductase is the best-studied genetic factor associated with variation in plasma tHCy, other candidate genes are being evaluated. Recently, we discovered that cystathioninuria was caused...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Carotid Stenosis
Share to MTHFR gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homocysteine

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 15151507
DOI: 10.1111/j.1399-0004.2004.00250.x

Genes

CTH
MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration.PMID 15151507Read ↗

Thermolabile methylenetetrahydrofolate reductase polymorphism (C677T) and total homocysteine concentration among African-American and white women.Semantic proximity Read ↗

Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.Semantic proximity Read ↗

Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine and other risk factors for vascular disease.Semantic proximity Read ↗

Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH).Semantic proximity Read ↗

Contribution of thermolabile methylenetetrahydrofolate reductase variant to total plasma homocysteine levels in healthy men and women. Inter99 (2).Semantic proximity Read ↗

Effect of genetic variants associated with plasma homocysteine levels on stroke risk.Semantic proximity Read ↗

Single nucleotide polymorphisms that affect homocysteine levels in Turkish population.Semantic proximity Read ↗

The common 'thermolabile' variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia.Semantic proximity Read ↗

The allele frequencies of three polymorphisms in genes involved in homocysteine metabolism in a group of unrelated healthy Singaporeans.Semantic proximity Read ↗

Genetic determinants of homocysteine thiolactonase activity in humans: implications for atherosclerosis.Semantic proximity Read ↗

Polymorphisms in the CBS gene associated with decreased risk of coronary artery disease and increased responsiveness to total homocysteine lowering by folic acid.Semantic proximity Read ↗

Polygenic influence on plasma homocysteine: association of two prevalent mutations, the 844ins68 of cystathionine beta-synthase and A(2756)G of methionine synthase, with lowered plasma homocysteine levels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.