Article
Polymorphisms in the CBS gene associated with decreased risk of coronary artery disease and increased responsiveness to total homocysteine lowering by folic acid.
Molecular genetics and metabolism - 1 May 2000
Kruger W D, Evans A A, Wang L, Malinow M R, Duell P B, Anderson P H, Block P C, Hess D L, Graf E E, Upson B
Abstract excerpt
Elevated total plasma homocysteine (tHcy) is an established risk factor for the development of vascular disease and neural tube defects. Total homocysteine levels can be lowered by folic acid supplements but individual response is highly variable. In this case-control study, involving 142 coronary artery disease (CAD) patients and 102 controls, we have typed six genetic polymorphisms in three homocysteine...
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