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Article

Contribution of thermolabile methylenetetrahydrofolate reductase variant to total plasma homocysteine levels in healthy men and women. Inter99 (2).

Genetic epidemiology - 1 May 2003

Husemoen Lise Lotte N, Thomsen Troels F, Fenger Mogens, Jørgensen Henrik L, Jørgensen Torben

Abstract excerpt

Elevation in plasma total homocysteine (tHcy) is believed to be causally related to cardiovascular disease. Like age and sex, the thermolabile variant of methylenetetrahydrofolate reductase (MTHFR(C677T)) is an important nonmodifiable determinant of tHcy, which may be considered when describing normal ranges of tHcy in the general population. We investigated the simultaneous effect of sex, age, and MTHFR(C677T)...

Topics

Adult
Age Factors
Female
Genotype
Homocysteine
Humans
Logistic Models
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Randomized Controlled Trials as Topic

Sex Characteristics

Source

Identifiers

PMID: 12687650
DOI: 10.1002/gepi.10239

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12687650-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Contribution of thermolabile methylenetetrahydrofolate reductase variant to total plasma homocysteine levels in healthy men and women. Inter99 (2).PMID 12687650Read ↗

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