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Article

Genetic determinants of homocysteine thiolactonase activity in humans: implications for atherosclerosis.

FEBS letters - 23 Feb 2001

Jakubowski H, Ambrosius W T, Pratt J H

Abstract excerpt

A metabolite of homocysteine (Hcy), the thioester Hcy thiolactone, damages proteins by modifying their lysine residues which may underlie Hcy-associated cardiovascular disease in humans. A protein component of high density lipoprotein, Hcy thiolactonase (HTase) hydrolyzes thiolactone to Hcy. Thio...

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Identifiers

PMID: 11226414
DOI: 10.1016/s0014-5793(01)02143-3

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11226414-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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