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Article

Effect of genetic variants associated with plasma homocysteine levels on stroke risk.

Stroke - 1 Jul 2014

Cotlarciuc Ioana, Malik Rainer, Holliday Elizabeth G, Ahmadi Kourosh R, Paré Guillaume, Psaty Bruce M, Fornage Myriam, Hasan Nazeeha, Rinne Paul E, Ikram M Arfan, Markus Hugh S, Rosand Jonathan, Mitchell Braxton D, Kittner Steven J, Meschia James F, van Meurs Joyce B J, Uitterlinden Andre G, Worrall Bradford B, Dichgans Martin, Sharma Pankaj

Abstract excerpt

BACKGROUND AND PURPOSE: Elevated total plasma homocysteine (tHcy) levels are known to be associated with increased risk of ischemic stroke (IS). Given that both tHcy and IS are heritable traits, we investigated a potential genetic relationship between homocysteine levels and stroke risk by assessing 18 polymorphisms previously associated with tHcy levels for their association with IS and its subtypes. METHODS:...

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Identifiers

PMID: 24846872
DOI: 10.1161/STROKEAHA.114.005208
PMCID: PMC4083192

Genes

MTHFR
RASIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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