Article
The common 'thermolabile' variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia.
QJM : monthly journal of the Association of Physicians - 1 Aug 1996
Harmon D L, Woodside J V, Yarnell J W, McMaster D, Young I S, McCrum E E, Gey K F, Whitehead A S, Evans A E
Abstract excerpt
Mild hyperhomocysteinaemia is a major risk factor for vascular disease and neural tube defects (NTDs), conferring an approximately three-fold relative risk for each condition. It has several possible causes: heterozygosity for rare loss of function mutations in the genes for 5,10-methylene tetrah...
Topics
- 5,10-Methylenetetrahydrofolate Reductase (FADH2)
- Adult
- Folic Acid
- Genotype
- Homocysteine
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Mutation
- Neural Tube Defects