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Alteration of Gene Expression in Normal-Appearing Colon Mucosa of APC min Mice and Human Cancer Patients

15 May 2004

Abstract excerpt

The expression of many genes is altered in colon cancer, but the roles of these genes in carcinogenesis are unclear. Using real-time quantitative PCR, we demonstrated that several genes previously implicated in human colon cancer undergo altered expression in the APC(min) mouse adenomatous polyp, a precursor of cancer, as well as in normal-appearing surrounding mucosa. The five genes that were most highly...

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PMID: 15150130
DOI: 10.1158/0008-5472.can-03-3264

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