Article
Colossal crypts bordering colon adenomas in Apc(Min) mice express full-length Apc.
The American journal of pathology - 1 Jun 1999
Bjerknes M, Cheng H
Abstract excerpt
Enlarged but nondysplastic crypts are frequently observed at the margins of colon tumors, forming what has been called a transitional epithelium. It is now thought that this is a reactive state and not a preneoplastic condition as previously suggested. We have used the mouse familial adenomatous polyposis model, ApcMin, to study these abnormal adenoma-associated crypts. We report that these nondysplastic crypts...
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