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Article

Microadenomatous lesions involving loss of Apc heterozygosity in the colon of adult Apc(Min/+) mice.

Cancer research - 15 Nov 2002

Yamada Yasuhiro, Hata Kazuya, Hirose Yoshinobu, Hara Akira, Sugie Shigeyuki, Kuno Toshiya, Yoshimi Naoki, Tanaka Takuji, Mori Hideki

Abstract excerpt

Mutations in the human adenomatous polyposis coli (APC) gene are causative for familial adenomatous polyposis (FAP), a rare condition in which numerous colonic polyps arise during puberty and, if left untreated, lead to colon cancer. Mouse model for human FAP, Apc(Min/+) mouse, contains a truncating mutation in the Apc gene and spontaneously develops intestinal adenomas. However, the distribution of tumors along...

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Identifiers

PMID: 12438216

Genes

FAP
APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Microadenomatous lesions involving loss of Apc heterozygosity in the colon of adult Apc(Min/+) mice.PMID 12438216Read ↗

Multistep carcinogenesis of the colon in Apc(Min/+) mouse.Semantic proximity Read ↗

Intestinal adenomas can develop with a stable karyotype and stable microsatellitesSemantic proximity Read ↗

Generation of a unique strain of multiple intestinal neoplasia (Apc+/Min‐FCCC) mice with significantly increased numbers of colorectal adenomasSemantic proximity Read ↗

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.Semantic proximity Read ↗

The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse.Semantic proximity Read ↗

A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in ApcMin/+ mice.Semantic proximity Read ↗

AOM-induced mouse colon tumors do not express full-length APC protein.Semantic proximity Read ↗

Colossal crypts bordering colon adenomas in Apc(Min) mice express full-length Apc.Semantic proximity Read ↗

Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway.Semantic proximity Read ↗

Complete deletion of Apc results in severe polyposis in mice.Semantic proximity Read ↗

Deletion of the WNT Target and Cancer Stem Cell Marker CD44 in Apc(Min/+) Mice Attenuates Intestinal TumorigenesisSemantic proximity Read ↗

Msh2 deficiency enhances somatic Apc and p53 mutations in Apc+/-Msh2-/- mice.Semantic proximity Read ↗

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