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Article

BRCA1 associates with processive RNA polymerase II.

The Journal of biological chemistry - 26 Dec 2003

Krum Susan A, Miranda Gustavo A, Lin Chenwei, Lane Timothy F

Abstract excerpt

The human BRCA1 tumor suppressor interacts with transcriptional machinery, including RNA polymerase II (RNA pol II). We demonstrated that interaction with RNA pol II is a conserved feature of BRCA1 proteins from several species. We found that full-length BRCA1 proteins universally fail to activate transcription in classic GAL4-UAS one-hybrid assays and that the activity associated with the human BRCA1 C terminus...

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Source

Identifiers

PMID: 14506230
DOI: 10.1074/jbc.M308418200

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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