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Article

Paf1 Has Distinct Roles in Transcription Elongation and Differential Transcript Fate.

Molecular cell - 16 Feb 2017

Fischl Harry, Howe Françoise S, Furger Andre, Mellor Jane

Abstract excerpt

RNA polymerase II (Pol2) movement through chromatin and the co-transcriptional processing and fate of nascent transcripts is coordinated by transcription elongation factors (TEFs) such as polymerase-associated factor 1 (Paf1), but it is not known whether TEFs have gene-specific functions. Using strand-specific nucleotide resolution techniques, we show that levels of Paf1 on Pol2 vary between genes, are controlled...

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Identifiers

PMID: 28190769
DOI: 10.1016/j.molcel.2017.01.006
PMCID: PMC5316414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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