Article
Deletion of one copy of the p16INK4A tumor suppressor gene is implicated as a predisposing factor in pediatric leukemia.
Biochemical and biophysical research communications - 11 Jun 2004
Carter Tina L, Terry Philippa, Gottardo Nicholas, Baker David L, Kees Ursula R, Watt Paul M
Abstract excerpt
The p16INK4A tumor suppressor gene is frequently disrupted by mutation or deletion in a wide range of cancer types, ranging from leukemia to cancers of the bladder, skin, lung, liver, and spleen. We have previously shown that deletion of at least one copy of the p16INK4A gene is associated with an increased risk of relapse in pediatric leukemia. Our data suggest that hemizygous p16INK4A deletion may be...
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