Article
Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemia.
Blood - 1 May 1995
Okuda T, Shurtleff S A, Valentine M B, Raimondi S C, Head D R, Behm F, Curcio-Brint A M, Liu Q, Pui C H, Sherr C J
Abstract excerpt
The tandemly linked p16INK4aMTS1 and p15INK4b/MTS2 genes on chromosome 9, band p21 encode proteins that function as specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. This locus undergoes frequent bi-allelic deletion in human cancer cell lines, suggesting that the encoded proteins may function as tumor suppressors. However, more recent analysis of primary tumor samples has shown a much lower...
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